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Tolerance Development : Not like morphine, which induces sizeable tolerance, this compound showed lowered tolerance in the new plate take a look at and managed analgesic efficacy as time passes
Q. How can this compound's pharmacological profile be optimized to cut back Uncomfortable side effects when retaining analgesia?
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Standardize Agonist Exposure Instances : this compound’s slow dissociation kinetics involve extended observation durations to capture whole β-arrestin recruitment .
This material is fairly new which is positioned for a research drug for chemical and scientific research, to detect pharmacological, analgesic options.
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In products of neuropathic suffering induced by chemotherapy agents, this compound exhibited higher potency and efficacy in comparison to morphine and oxycodone, retaining performance upon chronic administration
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Latest experiments have highlighted the comparative benefits of this compound more than traditional opioids: